Reaktion #1929062

Reaktionsgleichung

HCl

potassium hydrogen carbonate

6-(chloracetamido) hexanoic acid

potassium cyanide

→

6-(cyanacetamido)hexanoic acid

Lösungsmittel

water

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturwas cooled on ice
2. 2
   ExtraktionThe residue after extraction
3. 3
   Sonstigewas purified by chromatography (silica gel, solvent: ethyl acetate)

Vorschrift

2.8 g (20 mMol) potassium hydrogen carbonate was added to 8.3 g (40 mMol) 6-(chloracetamido) hexanoic acid dissolved in 25 ml water. 3.2 g (48 mMol) potassium cyanide was then added to the clear solution which was cooled on ice. The reaction mixture was stirred for 17 hours and was then acidified with HCl (2 N). The residue after extraction was purified by chromatography (silica gel, solvent: ethyl acetate).

Quelle