Reaktion #1929013

Reaktionsgleichung

triethyltrifluorovinylsilane

1-chloro-4-propylcyclohexane

4,4′-di-tert-butylbiphenyl

lithium

→

[(Z)-1,2-difluoro-2-(4-propylcyclohexyl)vinyl]triethylsilane

Lösungsmittel

Water

THF

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.ADDITIONare added at 0° C
2. 2
   TemperaturThe mixture is warmed slowly
3. 3
   Extraktionthe batch is extracted with MTBE
4. 4
   ExtraktionThe aqueous phase is extracted with MTBE
5. 5
   Waschenthe combined organic phases are washed with water and saturated sodium chloride solution
6. 6
   SonstigeThe solution is dried
7. 7
   Einengenconcentrated under reduced pressure
8. 8
   Filtrationis filtered off
9. 9
   EinengenThe filtrate is concentrated under reduced pressure
10. 10
    Sonstigethe residue is purified by column chromatography (SiO2, pentane)

Vorschrift

74.1 g (0.28 mol) of 4,4′-di-tert-butylbiphenyl are initially introduced in 1000 ml of THF in an argon atmosphere, and 1.6 g (0.23 mol) of lithium (granules) are added at 0° C. After 5 h, the blue solution is cooled to −78° C., and 40.6 g (0.25 mol) of 1-chloro-4-propylcyclohexane are added. After 30 min at this temperature, 49.6 g (0.25 mol) of triethyltrifluorovinylsilane are metered in. The mixture is warmed slowly and stirred at room temperature for 16 h. Water is added, and the batch is extracted with MTBE. The aqueous phase is extracted with MTBE, and the combined organic phases are washed with water and saturated sodium chloride solution. The solution is dried using sodium sulfate and concentrated under reduced pressure. The residue is digested with methanol, and insoluble material is filtered off. The filtrate is concentrated under reduced pressure, and the residue is purified by column chromatography (SiO2, pentane), giving [(Z)-1,2-difluoro-2-(4-propylcyclohexyl)vinyl]triethylsilane as a colourless oil.

Quelle