Reaktion #1925345

Reaktionsgleichung

4-chloro-2,6-bis-cyclopropyl-amino-pyrimidine-5-carbonitrile

1-phenyl-piperazine

N-ethyl-diisopropylamine

→

2,4-bis-cyclopropylamino-6-(4-phenyl-piperazin-1-yl)-pyrimidine-5-carbonitrile

Lösungsmittel

dioxane

Reaktionsbedingungen

Vorschrift

In analogy to the procedure described in example 20b, 4-chloro-2,6-bis-cyclopropyl-amino-pyrimidine-5-carbonitrile was treated with 1-phenyl-piperazine and N-ethyl-diisopropylamine in dioxane at 90° C. to yield 2,4-bis-cyclopropylamino-6-(4-phenyl-piperazin-1-yl)-pyrimidine-5-carbonitrile as an amorphous, light yellow solid; MS: [M+H]+376.

Quelle