Reaktion #1921530

Reaktionsgleichung

sarcosine

sodium hydroxide

chloroform

p-chlorobenzenesulfonyl chloride

→

N-p-chlorobenzenesulfonyl-sarcosine

Lösungsmittel

water

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeAfter the reaction
2. 2
   Sonstigethe aqueous layer is separated
3. 3
   Sonstigeto precipitate crystals
4. 4
   FiltrationThe crystals are collected by filtration
5. 5
   Sonstigerecrystallized from a mixed solvent

Vorschrift

4.3 Parts of sarcosine and 4.1 parts of sodium hydroxide are dissolved in 100 parts of water. To the resulting solution, 35 parts of chloroform containing 10 parts of p-chlorobenzenesulfonyl chloride is added, and the resulting mixture is stirred at 60° C for about 2 hours. After the reaction, the aqueous layer is separated and then acidified with hydrochloric acid to precipitate crystals. The crystals are collected by filtration and recrystallized from a mixed solvent comprising acetone and water to obtain 4.6 parts of N-p-chlorobenzenesulfonyl-sarcosine, m.p. 180.5°-182° C.

Quelle