Reaktion #1915636

Reaktionsgleichung

( F )

N8-[4-(tert-Butyl)-1,3-thiazol-2-yl]-4-oxo-3-(2H-1,2,3,4-tetrazol-5-yl)-4H-pyrido-[1,2-a]pyrimidine-8-carboxamide

3-[2-(4-methoxybenzyl)-2H-1,2,3,4-tetrazol-5-yl]-4-oxo-4H-pyrido[1,2-a]pyrimidine-8-carboxylic acid

4-(4-pyridyl)-1,3-thiazol-2-amine

→

title compound

N8-[4-(4-Pyridyl)-1,3-thiazol-2-yl]-4-oxo-3-(2 H-1,2,3,4-tetrazol-5-yl)-4H-pyrido-[1,2-a]pyrimidine-8-carboxamide

Reaktionsbedingungen

Vorschrift

Reactions were performed in the same manner as in Example 10, (F) by using 3-[2-(4-methoxybenzyl)-2H-1,2,3,4-tetrazol-5-yl]-4-oxo-4H-pyrido[1,2-a]pyrimidine-8-carboxylic acid (120 mg, 0.32 mmol) and 4-(4-pyridyl)-1,3-thiazol-2-amine (62 mg, 0.35 mmol) to obtain 35.7 mg (27% for the two steps) of the title compound as orange crystals.

Quelle