Reaktion #1915479

Reaktionsgleichung

2-Amino-3-pyridinol

chloroform

p-toluenesulfonic acid hydrate

→

title compound

2-(chloromethyl)[1,3]oxazolo[4,5-b]pyridine

Lösungsmittel

ethanol

diglyme

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturheated at 80° C. for an additional 48 hours
2. 2
   Temperaturto cool to room temperature
3. 3
   FiltrationThe mixture was filtered
4. 4
   Einengenthe filtrate concentrated under reduced pressure
5. 5
   workup.DISSOLUTIONThe residue was dissolved in methanol
6. 6
   Filtrationfiltered again
7. 7
   EinengenThe resulting filtrate was concentrated under reduced pressure

Vorschrift

2-Amino-3-pyridinol (1.1 g, Chemical Abstracts #16867-03-1) and chloromethyltrimethylorthoformate (2.27 g) were combined in diglyme (in 21 mL) and heated at 80° C. for 6 hours. The mixture was treated with p-toluenesulfonic acid hydrate (4 mg) and heated at 80° C. for an additional 48 hours. The mixture was allowed to cool to room temperature and diluted with chloroform (40 mL) and ethanol (10 mL). The mixture was filtered and the filtrate concentrated under reduced pressure. The residue was dissolved in methanol and filtered again. The resulting filtrate was concentrated under reduced pressure to provide the title compound and then dissolved in acetonitrile (35 mL) and used as a solution in the next step. 1H NMR (CDCl3, 300 MHz) δ 4.82 (2H, s), 7.38 (dd, 1H, J=8.7, 5.4 Hz), 7.89 (dd, 1H, J=8.7, 1.5 Hz), 8.62 (dd, 1H, J=5.4, 1.5 Hz). MS (DCI/NH3) m/z 169 (M+H)+.

Quelle