Reaktion #1915126

Reaktionsgleichung

2-phenylquinoline

ethanol

Sodium

2-phenylquinoline

→

2-phenyl-1,2,3,4-tetrahydroquinoline

Lösungsmittel

water

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeIn Scheme A, step 2, the 2-phenyl-1,2,3,4-tetrahydroquinoline of formula (3) is prepared
2. 2
   Extraktionextracted with a suitable organic solvent, such as methylene chloride, ethyl acetate, or chloroform
3. 3
   WaschenThe combined extracts may then be washed with water and brine
4. 4
   Sonstigethe organic layer is separated
5. 5
   Sonstigedried
6. 6
   Sonstigethe solvent is evaporated in vacuo

Vorschrift

In Scheme A, step 2, the 2-phenyl-1,2,3,4-tetrahydroquinoline of formula (3) is prepared by reducing 2-phenylquinoline of formula (2). For example, 2-phenylquinoline of formula (2) is dissolved in a suitable alcoholic solvent, such as absolute ethanol. Sodium metal is then added and the reaction is allowed to cool to room temperature. The reaction mixture may then be diluted with water and extracted with a suitable organic solvent, such as methylene chloride, ethyl acetate, or chloroform. The combined extracts may then be washed with water and brine, the organic layer is separated and dried and the solvent is evaporated in vacuo to provide the 2-phenyl-1,2,3,4-tetrahydroquinoline of formula (3) which may be used without further purification.

Quelle