Reaktion #1915078

Reaktionsgleichung

2-amino-4-phenylphenol

1-chloro-2,2,2-trimethoxyethane

→

2-(chloromethyl)-5-phenyl-benzoxazole

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe vial was sealed
2. 2
   Sonstigeabsorption level normal
3. 3
   TemperaturIt was then cooled to room temperature
4. 4
   workup.ADDITIONdiluted with 2 mL of methanol
5. 5
   Sonstigepurified by semi-prep HPLC
6. 6
   SonstigeThe HPLC fractions were evaporated under reduced pressure

Vorschrift

2-amino-4-phenylphenol (0.180 g, 0.97 mmol) was placed in a Smith Process Vial™ (Personal Chemistry, Inc., Uppsala) (3 mL glass vessel) followed by the addition of 1-chloro-2,2,2-trimethoxyethane (1 mL). The vial was sealed and the mixture was heated in the Emrys Optimizer™ (Personal Chemistry, Inc., Uppsala) microwave at 160° C. for 300 s, fixed hold time on, absorption level normal, pre-stirring 10 s. It was then cooled to room temperature, diluted with 2 mL of methanol and purified by semi-prep HPLC. The HPLC fractions were evaporated under reduced pressure to furnish 2-(chloromethyl)-5-phenyl-benzoxazole as an off-white solid.

Quelle