Reaktion #1910

Reaktionsgleichung

triethylamine

4-ethoxyaniline

ethyl methylthioacetate

chlorine

→

expected product

5-Ethoxy-1,3-dihydroindol-2-one

Lösungsmittel

water

DCM

DCM

DCM

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.STIRRINGThe mixture is stirred for one hour at about -70° C.
2. 2
   Sonstigethe organic phase is decanted
3. 3
   Trocknendried over magnesium sulfate
4. 4
   Sonstigeevaporated under reduced pressure
5. 5
   workup.STIRRINGThe mixture is stirred for about 16 hours at room temperature
6. 6
   Filtrationfiltered
7. 7
   Sonstigethe precipitate is separated off
8. 8
   EinengenThe filtrate is concentrated under reduced pressure

Vorschrift

23.6 g of ethyl methylthioacetate in 60 ml of DCM are added to a solution, cooled to about -70° C., of 12.5 g of chlorine in 400 ml of DCM. After stirring for 5 minutes at the same temperature, a solution of 4-ethoxyaniline (48.3 g) in 120 ml of DCM is added. The mixture is stirred for one hour at about -70° C., 39.3 ml of triethylamine are added and the resulting mixture is allowed to warm up to room temperature. 200 ml of water are added and the organic phase is decanted, dried over magnesium sulfate and evaporated under reduced pressure. The residue is taken up with 500 ml of isopropanol and 20 ml of concentrated hydrochloric acid. The mixture is stirred for about 16 hours at room temperature and filtered and the precipitate is separated off. The filtrate is concentrated under reduced pressure to give the expected product.

Quelle