Reaktion #1909791

Reaktionsgleichung

4-(4-hydroxyphenyl)benzoic acid

L-phenylalanine ethyl ester hydrochloride

WSC.HCl

HOBT

→

title compound

4-(4-Hydroxyphenyl)benzoyl-L-phenylalanine ethyl ester

Lösungsmittel

DMF

triethylamine

Water

Reaktionsbedingungen

Aufarbeitung

1. 1
   Extraktionthe mixture was extracted with ethyl acetate
2. 2
   WaschenThe organic layer was washed successively with a 10 % aqueous citric acid solution, water
3. 3
   Trocknena saturated aqueous sodium hydrogen-carbonate solution, water and saturated brine, dried over magnesium sodium sulfate
4. 4
   Einengenconcentrated under reduced pressure

Vorschrift

To a solution of 4-(4-hydroxyphenyl)benzoic acid (3.0 g) and L-phenylalanine ethyl ester hydrochloride (3.38 g) in DMF (30 ml) were added WSC.HCl (2.7 g), HOBT (1.89 g) and triethylamine (2 ml), and the mixture was stirred at room temperature for 14 hours. Water was added to the reaction mixture and the mixture was extracted with ethyl acetate. The organic layer was washed successively with a 10 % aqueous citric acid solution, water, a saturated aqueous sodium hydrogen-carbonate solution, water and saturated brine, dried over magnesium sodium sulfate, and concentrated under reduced pressure to give a crude product of the title compound.

Quelle