Reaktion #1909788
ord-0eafee68ac1d45dd8d917a72f88f747b
Reaktionsgleichung
2-(4-methylpiperazin-1-yl) ethanol
3,5-dichloro-2,4-dihydroxybenzoic acid methyl ester
triphenylphosphine
Hydrochloric acid
→
title compound
3,5-Dichloro-2-hydroxy-4-[2-(4-methylpiperazin-1-yl)-ethoxy]benzoic acid methyl ester
Edukte
Reagenzien
Keine
Lösungsmittel
Reaktionsbedingungen
Detaillierte Bedingungen
See reaction.notes.procedure_details.
Vorschrift
To a solution of 2-(4-methylpiperazin-1-yl) ethanol (14.42 g) and 3,5-dichloro-2,4-dihydroxybenzoic acid methyl ester (52.15 g) in chloroform (400 ml) were added triphenylphosphine (28.85 g) and azodicarboxylic acid diisopropyl (21.7 ml) at room temperature, and the mixture was stirred for 16 hours, 1N Hydrochloric acid (300 ml) was added to the reaction mixture for extraction to give a crude product of the title compound. Step 4) 3,5-Dichloro-2-hydroxy-4-[2-(4-methylpiperazin-1-yl)ethoxy]-benzoic acid (VII)