Reaktion #1908843

Reaktionsgleichung

3,4,6-trichloropyridazine

sodium hydride

pyrocatechol

→

3-chloro[1,4]benzodioxino[2,3-c]pyridazine

Ausbeute 69.7%

Lösungsmittel

1,4-dioxane

1,4-dioxane

1,4-dioxane

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperatur218 to 221}, and the mixture was refluxed for 2 hours
2. 2
   workup.ADDITIONThe reaction mixture was poured into ice-cold water
3. 3
   Extraktionextracted with ethyl acetate
4. 4
   Waschenwashed successively with 1 mol/L sodium hydroxide and water
5. 5
   Trocknendried over anhydrous magnesium sulfate
6. 6
   SonstigeThe solvent was removed
7. 7
   Sonstigethe residue was recrystallized from methyl isobutyl ketone

Vorschrift

In 1,4-dioxane (30 mL) was suspended 3.49 g (80.0 mmol) of 55% sodium hydride, and to the suspension were added a 1,4-dioxane (30 mL) solution containing 4.40 g (40 mmol) of pyrocatechol, then a 1,4-dioxane (30 mL) solution containing 7.30 g (39.9 mmol) of 3,4,6-trichloropyridazine {described in The Journal of Organic Chemistry, 1963, vol. 28, pp. 218 to 221}, and the mixture was refluxed for 2 hours. The reaction mixture was poured into ice-cold water, and extracted with ethyl acetate. The organic layers were combined, washed successively with 1 mol/L sodium hydroxide and water, and dried over anhydrous magnesium sulfate. The solvent was removed, and the residue was recrystallized from methyl isobutyl ketone to obtain 6.15 g (27.8 mmol, Yield: 69.7%) of 3-chloro[1,4]benzodioxino[2,3-c]pyridazine.

Quelle