Reaktion #1907740

ord-8a18e5c7a7f345bd88c9f2bc52d1a613

Reaktionsgleichung

CC(C)n1c(C(=O)O)cc2cc(C(=O)N3CCCC(N(C)C)C3)ccc21
5-(3-dimethylamino-piperidine-1-carbonyl)-1-isopropyl-1H-indole-2-carboxylic acid
O=S1(=O)CCNCC1
thiomorpholine 1,1-dioxide
CCN=C=NCCCN(C)C.Cl
1-ethyl-3-(3-dimethylaminopropyl)-carbodiimide hydrochloride
→
CC(C)n1c(C(=O)N2CCS(=O)(=O)CC2)cc2cc(C(=O)N3CCCC(N(C)C)C3)ccc21
title compound
CC(C)n1c(C(=O)N2CCS(=O)(=O)CC2)cc2cc(C(=O)N3CCCC(N(C)C)C3)ccc21
[5-(3-Dimethylamino-piperidine-1-carbonyl)-1-isopropyl-1H-indol-2-yl]-(1,1-dioxo-thiomorpholin-4-yl)-methanone

Edukte

CC(C)n1c(C(=O)O)cc2cc(C(=O)N3CCCC(N(C)C)C3)ccc21
5-(3-dimethylamino-piperidine-1-carbonyl)-1-isopropyl-1H-indole-2-carboxylic acid
O=S1(=O)CCNCC1
thiomorpholine 1,1-dioxide
CCN=C=NCCCN(C)C.Cl
1-ethyl-3-(3-dimethylaminopropyl)-carbodiimide hydrochloride

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

The title compound was synthesized in analogy to Example 1, from 5-(3-dimethylamino-piperidine-1-carbonyl)-1-isopropyl-1H-indole-2-carboxylic acid, thiomorpholine 1,1-dioxide and 1-ethyl-3-(3-dimethylaminopropyl)-carbodiimide hydrochloride, to afford the product as an off-white solid (15%).

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US07601711B2uspto-grants-2009_10