Reaktion #1907736

ord-75731a4f685046c0b34eb88941f0bf43

Reaktionsgleichung

CCOC(=O)c1cc2cc(C(=O)O)ccc2[nH]1
1H-indole-2,5-dicarboxylic acid 2-ethyl ester
CN(C)C1CCCNC1
3-dimethylamino-piperidine
CCN=C=NCCCN(C)C.Cl
1-ethyl-3-(3-dimethylaminopropyl)-carbodiimide hydrochloride
→
CCOC(=O)c1cc2cc(C(=O)N3CCCC(N(C)C)C3)ccc2[nH]1
title compound
CCOC(=O)c1cc2cc(C(=O)N3CCCC(N(C)C)C3)ccc2[nH]1
Ethyl 5-(3-dimethylamino-piperidine-1-carbonyl)-1H-indole-2-carboxylate

Edukte

CCOC(=O)c1cc2cc(C(=O)O)ccc2[nH]1
1H-indole-2,5-dicarboxylic acid 2-ethyl ester
CN(C)C1CCCNC1
3-dimethylamino-piperidine
CCN=C=NCCCN(C)C.Cl
1-ethyl-3-(3-dimethylaminopropyl)-carbodiimide hydrochloride
—
Intermediate 1a

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

The title compound was synthesized in analogy to Example 1, Intermediate 1a), from 1H-indole-2,5-dicarboxylic acid 2-ethyl ester, 3-dimethylamino-piperidine and 1-ethyl-3-(3-dimethylaminopropyl)-carbodiimide hydrochloride, to afford the product as a light-brown solid (63%).

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US07601711B2uspto-grants-2009_10