Reaktion #1907073

Reaktionsgleichung

N-Boc-L-phenylalanine

triethylamine

1-(3-dimethylaminopropyl)-3-ethylcarbodiimide

7,8,9,10-tetrahydro-6H-benzo[b]-cyclohepta[d]furan-2-ylamine

N-hydroxybenzotriazole

→

tert-butyl [(1S)-1-benzyl-2-oxo-2-(7,8,9,10-tetrahydro-6H-benzo[b]cyclohepta[d]furan-2-ylamino)ethyl]carbamate

Ausbeute 39.0%

Reaktionsbedingungen

Vorschrift

Following the procedure of Example 30, triethylamine (0.43 mL, 3.1 mmol), 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide (0.31 g, 1.6 mmol), N-hydroxybenzotriazole (0.22 g, 1.6 mmol), N-Boc-L-phenylalanine (0.36 g, 1.4 mmol), and 7,8,9,10-tetrahydro-6H-benzo[b]-cyclohepta[d]furan-2-ylamine (0.25 g, 1.2 mmol) provided tert-butyl [(1S)-1-benzyl-2-oxo-2-(7,8,9,10-tetrahydro-6H-benzo[b]cyclohepta[d]furan-2-ylamino)ethyl]carbamate (0.21 g). MS (ESI) m/z 449 ([M+H]+); MS (ESI) m/z 447.3 ([M−H]−).

Quelle