Reaktion #1904601

Reaktionsgleichung

(1S)-1-phenylpropylamine

triethylamine

4-[(6,7-Dimethoxy-4-quinolyl)oxy]aniline

triphosgene

→

title compound

Ausbeute 121.9%

N-{4-[(6,7-Dimethoxy-4-quinolyl)oxy]phenyl}-N′-[(1S)-1-phenylpropyl]urea

Ausbeute 121.9%

Lösungsmittel

chloroform

chloroform

chloroform

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.STIRRINGthe mixture was stirred at room temperature for 10 hr
2. 2
   SonstigeThe stirred mixture was purified by chromatography on silica gel

Vorschrift

4-[(6,7-Dimethoxy-4-quinolyl)oxy]aniline (70 mg) was dissolved in chloroform (1 ml) and triethylamine (0.1 ml) to prepare a solution. A solution of triphosgene (33 mg) in chloroform (0.2 ml) was then added to the solution, and the mixture was stirred at room temperature for 75 min. Next, a solution of (1S)-1-phenylpropylamine (31 mg) in chloroform (0.2 ml) was added thereto, and the mixture was stirred at room temperature for 10 hr. The stirred mixture was purified by chromatography on silica gel using chloroform/methanol for development to give the title compound (62 mg, yield 57%).

Quelle