Reaktion #1904566

Reaktionsgleichung

Water

2-acetyl thiazole

hydroxylamine hydrochloride

Pyridine

→

title compound

Ausbeute 88.0%

1-(1,3-Thiazol-2-yl)-1-ethanone oxime

Ausbeute 88.0%

Lösungsmittel

ethanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigeto prepare a solution
2. 2
   Extraktionthe mixture was extracted three times with ethyl acetate
3. 3
   WaschenThe organic layer was washed with water
4. 4
   Trocknenwas dried over sodium sulfate
5. 5
   SonstigeThe solvent was removed by evaporation
6. 6
   Sonstigewas dried by means of a vacuum pump

Vorschrift

Commercially available 2-acetyl thiazole (1.27 g) and commercially available hydroxylamine hydrochloride (830 mg) were dissolved in ethanol (40 ml) to prepare a solution. Pyridine (0.97 ml) was added to the solution, and the mixture was stirred at room temperature overnight. Water was added to the reaction solution, and the mixture was extracted three times with ethyl acetate. The organic layer was washed with water and was dried over sodium sulfate. The solvent was removed by evaporation and was dried by means of a vacuum pump to give the title compound (1.25 g, 88%).

Quelle