Reaktion #1904035

Reaktionsgleichung

L-lysine

succinic anhydride

triethyl amine

→

Lysine Succinimide

Lösungsmittel

N,N-dimethyl formamide

Reaktionsbedingungen

Aufarbeitung

1. 1
   TemperaturAt the end of 6 h period, the solution is cooled
2. 2
   Sonstigesolvent is removed by vacuum distillation
3. 3
   SonstigeThe crude product is purified by flash chromatography
4. 4
   SonstigeIt is then immediately used in next reaction

Vorschrift

In this example that demonstrates how this method could be performed, 2 g of L-lysine is dissolved in 200 ml dry N,N-dimethyl formamide (DMF) in a 500 ml round bottom flask. 10.7 g succinic anhydride and 20 ml triethyl amine are added under nitrogen atmosphere. The mixture is heated to 60° C. for 6 h. At the end of 6 h period, the solution is cooled and solvent is removed by vacuum distillation. The crude product is purified by flash chromatography. It is then immediately used in next reaction.

Quelle