Reaktion #1903777

Reaktionsgleichung

2-diethylphosphonopropionic acid

ethyl 3-[3-(aminomethyl)-4-methoxyphenyl]-2-isopropoxypropionate

diethyl cyanophosphonate

triethylamine

→

ethyl 3-[3-([2-(diethoxyphosphoryl)propanoyl]aminomethyl)-4-methoxyphenyl]-2-isopropoxypropionate

Ausbeute 87.8%

Lösungsmittel

N,N-dimethylformamide

ethyl acetate

Reaktionsbedingungen

Aufarbeitung

1. 1
   WaschenThe organic layer was washed with water and brine
2. 2
   Trocknendried over anhydrous magnesium sulfate
3. 3
   Sonstigethe solvent was evaporated

Vorschrift

643 mg of 2-diethylphosphonopropionic acid and 973 mg of ethyl 3-[3-(aminomethyl)-4-methoxyphenyl]-2-isopropoxypropionate were dissolved in 10 ml N,N-dimethylformamide, and 470 μl diethyl cyanophosphonate and 1.07 ml triethylamine were successively added thereto. The mixture was stirred overnight at room temperature, and the reaction mixture was diluted with ethyl acetate. The organic layer was washed with water and brine, dried over anhydrous magnesium sulfate and the solvent was evaporated, to give 1.310 g of ethyl 3-[3-([2-(diethoxyphosphoryl)propanoyl]aminomethyl)-4-methoxyphenyl]-2-isopropoxypropionate.

Quelle