Reaktion #1901751

Reaktionsgleichung

2-Ethoxycarbonyl-5-(tributylstannyl)indane

3-bromo-1-(4-ethylpiperazin-1-yl)isoquinoline

→

1-(4-ethylpiperazin-1-yl)-3-(2-ethoxycarbonylindan-5-yl)isoquinoline

Ausbeute 90.8%

Lösungsmittel

ethyl acetate

xylene

Reaktionsbedingungen

Aufarbeitung

1. 1
   TemperaturAfter cooling
2. 2
   Filtrationfiltered
3. 3
   ExtraktionThe filtrate was extracted with 2N hydrochloric acid
4. 4
   Waschenthe resulting aqueous layer was washed with ethyl acetate
5. 5
   Extraktionextracted with ethyl acetate
6. 6
   WaschenThe extract was washed with a 10% aqueous solution of sodium carbonate and brine
7. 7
   Trocknendried over magnesium sulfate
8. 8
   SonstigeThe solvent was evaporated

Vorschrift

2-Ethoxycarbonyl-5-(tributylstannyl)indane (3.04 g) and 3-bromo-1-(4-ethylpiperazin-1-yl)isoquinoline (0.87 g) were heated under reflux overnight in the presence of tetrakistriphenylphosphinepalladium(0) (0.12 g) in xylene in nitrogen atmosphere. After cooling, the reaction solution was diluted with ethyl acetate and filtered. The filtrate was extracted with 2N hydrochloric acid, and the resulting aqueous layer was washed with ethyl acetate, adjusted to pH 10 with a 8N aqueous solution of sodium hydroxide, and then extracted with ethyl acetate. The extract was washed with a 10% aqueous solution of sodium carbonate and brine, and dried over magnesium sulfate. The solvent was evaporated, to give 1-(4-ethylpiperazin-1-yl)-3-(2-ethoxycarbonylindan-5-yl)isoquinoline (1.06 g) as a brown viscous oil.

Quelle