Reaktion #1891085

Reaktionsgleichung

6-chloro-2-phenyl-3-pyrid-4-ylimidazo[1,2-b]pyridazine

4-pyrrolidin-1-ylpiperidine

→

yellow crystals

Ausbeute 27.0%

2-Phenyl-3-pyrid-4-yl-6-(4-pyrrolidin-1-ylpiperid-1-yl)imidazo[1,2-b]pyridazine

Ausbeute 27.0%

Lösungsmittel

ethanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   TemperaturAfter cooling
2. 2
   Sonstigethe solvent is evaporated off under reduced pressure
3. 3
   Sonstigethe residue is chromatographed on silica gel
4. 4
   Wascheneluting with a mixture of dichloromethane and methanol (93:7)
5. 5
   SonstigeThe product is then recrystallized from 40 mL of methanol

Vorschrift

A mixture of 4.03 g (13.1 mmol) of 6-chloro-2-phenyl-3-pyrid-4-ylimidazo[1,2-b]pyridazine and 4.4 g (29 mmol) of 4-pyrrolidin-1-ylpiperidine in 50 mL of ethanol is heated at 155° C. for 4 hours. After cooling, the solvent is evaporated off under reduced pressure and the residue is chromatographed on silica gel, eluting with a mixture of dichloromethane and methanol (93:7). The product is then recrystallized from 40 mL of methanol to give 1.5 g of yellow crystals after drying under reduced pressure.

Quelle