Reaktion #1887

Reaktionsgleichung

sodium cyanoborohydride

2-amino-5-chloro-α-(2,4,6-trimethoxyphenyl)benzyl alcohol

trimethylacetaldehyde

acetic acid

→

crystal

5-chloro-α-(2,4,6-trimethoxyphenyl)-2-(neopentylamino)benzyl alcohol

Lösungsmittel

ethanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   EinengenAfter concentration and subsequent dilution with water
2. 2
   Extraktionthe solution was extracted with ethyl acetate
3. 3
   SonstigeAfter solvent removal

Vorschrift

After a solution of 2.5 g of 2-amino-5-chloro-α-(2,4,6-trimethoxyphenyl)benzyl alcohol, 1.01 ml of trimethylacetaldehyde and 0.56 g of acetic acid in 30 ml of ethanol was stirred at room temperature for 1.5 hours, 0.81 g of sodium cyanoborohydride was added, followed by stirring overnight. After concentration and subsequent dilution with water, the solution was extracted with ethyl acetate. After solvent removal, the residue was subjected to silica gel column chromatography to yield 2.2 g of a crystal.

Quelle