Reaktion #1886

Reaktionsgleichung

water

2-amino-5-chloro-2',4',6'-trimethoxybenzophenone

lithium aluminum hydride

→

crystal

Ausbeute 96.1%

2-amino-5-chloro-α-(2,4,6-trimethoxyphenyl)benzyl alcohol

Ausbeute 96.1%

Lösungsmittel

tetrahydrofuran

Reaktionsbedingungen

Aufarbeitung

1. 1
   Extraktionthe solution was extracted with ethyl acetate
2. 2
   Trocknendried over anhydrous sodium sulfate
3. 3
   Sonstigeafter which the solvent was removed

Vorschrift

To a solution of 3.0 g of 2-amino-5-chloro-2',4',6'-trimethoxybenzophenone in 50 ml of tetrahydrofuran, 0.43 g of lithium aluminum hydride was added, followed by stirring for 1 hour. After water was added, the solution was extracted with ethyl acetate and dried over anhydrous sodium sulfate, after which the solvent was removed and the residue was subjected to silica gel column chromatography to yield 2.9 g of a crystal.

Quelle