Reaktion #1885922

ord-bedeb7b726414935abf79948282ba1ec

Reaktionsgleichung

CC(C)(C)OC(=O)Cn1nc(C2=NCCN2)c2c(N)ncnc21
tert-butyl 2-(4-amino-3-(4,5-dihydro-1H-imidazol-2-yl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)acetate
→
CC(C)(C)OC(=O)Cn1nc(-c2ncc[nH]2)c2c(N)ncnc21
tert-butyl 2-(4-amino-3-(1H-imidazol-2-yl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)acetate

Edukte

CC(C)(C)OC(=O)Cn1nc(C2=NCCN2)c2c(N)ncnc21
tert-butyl 2-(4-amino-3-(4,5-dihydro-1H-imidazol-2-yl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)acetate

Reagenzien

Keine

Lösungsmittel

CS(C)=O
DMSO

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

As shown tert-butyl 2-(4-amino-3-(4,5-dihydro-1H-imidazol-2-yl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)acetate can be oxidized with DMP in the presence of the solvent DMSO to obtain tert-butyl 2-(4-amino-3-(1H-imidazol-2-yl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)acetate.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US08343975B2uspto-grants-2013_01