Reaktion #1884963

Reaktionsgleichung

N-tert-butyl-(3-chloro)propylsulfonamide

n-BuLi

→

desired product

Ausbeute 56.4%

Cyclopropanesulfonic Acid tert-Butylamide

Ausbeute 56.4%

Lösungsmittel

THF

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe volatiles were removed in vacuo
2. 2
   SonstigeThe residue was partitioned between EtOAC and water (200 mL, 200 mL)
3. 3
   WaschenThe separated organic phase was washed with brine
4. 4
   Trocknendried over Na2SO4
5. 5
   Filtrationfiltered
6. 6
   Einengenconcentrated in vacuo
7. 7
   SonstigeThe residue was recrystallized from hexane

Vorschrift

To a solution of N-tert-butyl-(3-chloro)propylsulfonamide (2.14 g, 10.0 mmol) in THF (100 mL) was added n-BuLi (2.5 M in hexane, 8.0 mL, 20.0 mmol) at −78° C. The reaction mixture was allowed to warm up to room temperature over period of 1 h. The volatiles were removed in vacuo. The residue was partitioned between EtOAC and water (200 mL, 200 mL). The separated organic phase was washed with brine, dried over Na2SO4, filtered and concentrated in vacuo. The residue was recrystallized from hexane to yield the desired product as a white solid (1.0 g, 56%).

Quelle