Reaktion #1883111

ord-cb83fa3d00d742b7911c5036706b73a1

Reaktionsgleichung

CCC(=O)NC1CCc2nc(N)sc2C1
N-(2-amino-4,5,6,7-tetrahydro-1,3-benzothiazol-6-yl)propanamide
Cc1cc(Cl)cc(Cl)c1S(=O)(=O)Cl
2,4-dichloro-6-methylbenzenesulfonyl chloride
→
CCC(=O)NC1CCc2nc(NS(=O)(=O)c3c(C)cc(Cl)cc3Cl)sc2C1
title compound
CCC(=O)NC1CCc2nc(NS(=O)(=O)c3c(C)cc(Cl)cc3Cl)sc2C1
N-(2-{[(2,4-dichloro-6-methylphenyl)sulfonyl]amino}-4,5,6,7-tetrahydro-1,3-benzothiazol-6-yl)propanamide

Edukte

CCC(=O)NC1CCc2nc(N)sc2C1
N-(2-amino-4,5,6,7-tetrahydro-1,3-benzothiazol-6-yl)propanamide
Cc1cc(Cl)cc(Cl)c1S(=O)(=O)Cl
2,4-dichloro-6-methylbenzenesulfonyl chloride

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

The title compound was prepared from N-(2-amino-4,5,6,7-tetrahydro-1,3-benzothiazol-6-yl)propanamide (47 mg, 0.21 mmol) and 2,4-dichloro-6-methylbenzenesulfonyl chloride as described in the synthetic METHOD B to give a white solid (20.3 mg) with purity >90%. MS (pos) m/z 448.1, 450.1.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US07030135B2uspto-grants-2006_04