Reaktion #1882147

Reaktionsgleichung

(thymin-1-yl)-acetic acid

1-(2-nitro-benzenesulfonyl)-3-phenyl-piperazin-2-one HCl salt

PyBOP

N,N-diisopropylethylamine

→

titled compound

Ausbeute 43.3%

1-(2-Nitro-benzensulfonyl)-3-phenyl-4-[(thymin-1-yl)acetyl]-piperazin-2-one

Ausbeute 43.3%

Lösungsmittel

DMF

Reaktionsbedingungen

Aufarbeitung

1. 1
   Einengenthe reaction mixture was concentrated under reduced pressure
2. 2
   SonstigeThe residue was purified by column chromatography

Vorschrift

To a solution of (thymin-1-yl)-acetic acid (13 mg, 0.071 mmol), 1-(2-nitro-benzenesulfonyl)-3-phenyl-piperazin-2-one HCl salt (28 mg, 0.070 mmol), and PyBOP (40 mg, 0.077 mmol) in DMF (0.3 mL) was added N,N-diisopropylethylamine (0.018 mL) at room temperature. After stirring for additional 27 h, the reaction mixture was concentrated under reduced pressure. The residue was purified by column chromatography to give the titled compound (16 mg, 43%). 1H NMR (500 MHz; DMSO-d6) δ 11.33 (s, 1H), 8.36 (d, 1H), 8.13 (d, 1H), 8.05˜7.94 (m, 3H), 7.39˜7.29 (m, 5H), 5.93 (s, 1H), 4.87 (d, 1H), 4.67 (d, 1H), 4.22˜4.16 (m, 2H), 3.96 (m, 1H), 3.78 (m, 1H), 1.74 (s, 3H).

Quelle