Reaktion #1879037

Reaktionsgleichung

Benzenesulfonyl chloride

amino-3-[2-(4-cyanophenyl)ethoxy]-2-methylbenzene

Amino-3-[2-(4-cyanophenyl)ethoxy]-2-methylbenzene

→

sub-title compound

Ausbeute 72.0%

N-{3-[2-(4-Cyanophenyl)ethoxy]-2-methylphenyl}benzenesulfonamide

Ausbeute 72.0%

Lösungsmittel

pyridine

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeAfter evaporation of the solvent the residue
2. 2
   Sonstigewas partitioned between 10% aqueous HCl and EtOAc
3. 3
   WaschenThe organic layer was washed with brine
4. 4
   Trocknendried (MgSO4)
5. 5
   Sonstigethe solvent removed in vacuo
6. 6
   SonstigePurification by flash chromatography

Vorschrift

Benzenesulfonyl chloride (0.24 mL; 1.9 mmol) was added to a stirred solution of amino-3-[2-(4-cyanophenyl)ethoxy]-2-methylbenzene (0.42 g ; 1.7 mmol; from step (iii) above) in dry pyridine (20 mL) under nitrogen. The reaction was left overnight at room temperature. After evaporation of the solvent the residue was partitioned between 10% aqueous HCl and EtOAc. The organic layer was washed with brine, dried (MgSO4) and the solvent removed in vacuo. Purification by flash chromatography afforded 0.47 g (72%) of the sub-title compound.

Quelle