Reaktion #1875807

Reaktionsgleichung

2-methylamino-4-(2-methoxyethylthio)-6-methylpyrimidine

2-nitrobenzenesulfonylisocyanate

→

N-[N-[4-(2-methoxyethylthio)-6-methylpyrimidin-2-yl]-N-methylaminocarbonyl]-2-nitrobenzenesulfonamide

Lösungsmittel

methylene chloride

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigethe compounds of Table 3 can be prepared
2. 2
   Sonstigeat ambient temperature
3. 3
   Temperaturrefluxed for 4 hours
4. 4
   Sonstigethe methylene chloride is removed under reduced pressure
5. 5
   SonstigeThe resulting solid is triturated with 1-chlorobutane

Vorschrift

By using the procedure of Equation 2 with an equivalent amount of appropriate 2-methylaminopyrimidines or 2-methylamino-1,3,5-triazines and appropriately substituted benzenesulfonylisocyanates or isothiocyanates, the compounds of Table 3 can be prepared. For example, to a dry stirred solution of 19.7 parts of 2-methylamino-4-(2-methoxyethylthio)-6-methylpyrimidine in 300 parts of methylene chloride at ambient temperature is added 22.8 parts of 2-nitrobenzenesulfonylisocyanate. That mixture is stirred and refluxed for 4 hours, and then the methylene chloride is removed under reduced pressure. The resulting solid is triturated with 1-chlorobutane to yield N-[N-[4-(2-methoxyethylthio)-6-methylpyrimidin-2-yl]-N-methylaminocarbonyl]-2-nitrobenzenesulfonamide.

Quelle