Reaktion #1875690
ord-2a5ab8982e364511ad1f2a069c8b9e89
Reaktionsgleichung
KOH
1-[2-chloro-4-(4-chloro-phenoxy)-phenyl]-ethanone
Compound 354
2-[2-(5-Bromo-2-hydroxy-phenyl)-quinolin-6-yl]-1-cyclohexyl-1H-benzoimidazole-5-carboxylic acid
→
title compound
Ausbeute 49.0%
2-{2-[2-chloro-4-(4-chloro-phenoxy)-phenyl]-quinolin-6-yl}-1-cyclohexyl-1H-benzoimidazole-5-carboxylic acid
Ausbeute 49.0%
Edukte
Reagenzien
Keine
Reaktionsbedingungen
Detaillierte Bedingungen
See reaction.notes.procedure_details.
Vorschrift
Following the procedure and workup for Compound 354, Compound 354e (100 mg, 0.256 mmol) was reacted with 1-[2-chloro-4-(4-chloro-phenoxy)-phenyl]-ethanone (0.256 mmol) in ethanol (2 mL) using 10% w/v KOH in ethanol (506 μL, 0.64 mmol) to produce the title compound (75 mg, 49% yield). MS: 608.17 (M+H+); HPLC Procedure B, retention time=8.44 min.