Reaktion #1874334

Reaktionsgleichung

1-(4-methylphenyl)-2-(2,3,5-trimethylphenoxy)ethanone

→

title compound

Ausbeute 83.0%

4,6,7-Trimethyl-3-(4-methylphenyl)-1-benzofuran

Ausbeute 83.0%

Lösungsmittel

Water

Reaktionsbedingungen

Aufarbeitung

1. 1
   Extraktionwas extracted with ethyl acetate
2. 2
   WaschenThe organic layer was washed with a saturated sodium hydrogen carbonate solution
3. 3
   Trocknendried over anhydrous sodium sulfate
4. 4
   Einengenconcentrated under reduced pressure

Vorschrift

A mixture of 1-(4-methylphenyl)-2-(2,3,5-trimethylphenoxy)ethanone obtained in Reference Example 163 (1.0 g, 3.73 mmol) and polyphosphoric acid (6.0 g) was stirred at 80° C. for one and half hours. Water was added to the reaction solution, which was extracted with ethyl acetate. The organic layer was washed with a saturated sodium hydrogen carbonate solution, dried over anhydrous sodium sulfate, and then concentrated under reduced pressure to obtain 770 mg (yield 83%) of the title compound. Melting point: 112-113° C. (ethyl acetate-methanol).

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