Reaktion #1871428

Reaktionsgleichung

acetic acid

(S)-2-(2-amino-5-chloro-benzoylamino)-3-(4′-phenoxy-biphenyl-4-yl)propionic acid methyl ester

sodium triacetoxyborohydride

6-oxo-hexanoic acid methyl ester

→

(S)-6-{4-Chloro-2-[1-methoxycarbonyl-2-(4′-phenoxy-biphenyl-4-yl)-ethylcarbamoyl]-phenylamino}-hexanoic acid methyl ester

Lösungsmittel

DCE

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigePurification by flash chromatography (ethyl acetate/hexanes 1:3)

Vorschrift

(S)-6-{4-Chloro-2-[1-methoxycarbonyl-2-(4′-phenoxy-biphenyl-4-yl)-ethylcarbamoyl]-phenylamino}-hexanoic acid methyl ester was prepared following Procedure G using (S)-2-(2-amino-5-chloro-benzoylamino)-3-(4′-phenoxy-biphenyl-4-yl)propionic acid methyl ester (401 mg, 0.8 mmol), 6-oxo-hexanoic acid methyl ester (231 mg, 1.6 mmol), acetic acid (2.4 mmol), sodium triacetoxyborohydride (437 mg, 97%, 2 mmol) and DCE (6 mL). Purification by flash chromatography (ethyl acetate/hexanes 1:3) gave the title compound as yellow oil (418 mg).

Quelle