Reaktion #1869203

Reaktionsgleichung

cis-4-tert-Butoxycarbonylamino-3-hydroxy-piperidine-1-carboxylic acid benzyl ester

→

white solid

Ausbeute 100.5%

cis-(3-Hydroxy-piperidin-4-yl)-carbamic acid tert-butyl ester

Ausbeute 100.5%

Lösungsmittel

methanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigewas degassed
2. 2
   workup.ADDITIONPearlman's catalyst (palladium hydroxide on carbon, 20wt % Pd (dry basis), ≦50% water, 500 mg) was added
3. 3
   Sonstigethe mixture was purged with hydrogen
4. 4
   SonstigeThe mixture was degassed with argon
5. 5
   Filtrationfiltered through a pad of Celite
6. 6
   Sonstigeevaporated to dryness

Vorschrift

10.0 g of cis-4-tert-Butoxycarbonylamino-3-hydroxy-piperidine-1-carboxylic acid benzyl ester slow running Isomer 2 (10b), was dissolved in methanol (350 mL) and was degassed. Pearlman's catalyst (palladium hydroxide on carbon, 20wt % Pd (dry basis), ≦50% water, 500 mg) was added and the mixture was purged with hydrogen and stirring continued under a balloon of hydrogen for 12 hours. The mixture was degassed with argon, filtered through a pad of Celite, and evaporated to dryness to afford 6.2 g (100%) of a white solid.

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