Reaktion #1869200

Reaktionsgleichung

5-benzyloxy-2-hydroxymethyl-4-pyrone

Kojic acid

ammonia

Erol

→

5-Benzyloxy-2-hydroxymethyl-1 H-pyridin-4-one

Lösungsmittel

ethanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturto reflux overnight
2. 2
   Filtrationthen filtered
3. 3
   WaschenThe resultant solid was washed with ether
4. 4
   Sonstigedried in vacuo (5.9 g)

Vorschrift

A mixture of 5-benzyloxy-2-hydroxymethyl-4-pyrone (prepared from Kojic acid by the method of D. Erol, J. Med. Chem., 1994, 29, 893) (9.7 g, 40 mmol), concentrated aqueous (880) ammonia (100 mL), and ethanol (20 mL) was heated to reflux overnight. The mixture was allowed to cool to room temperature then filtered. The resultant solid was washed with ether and dried in vacuo (5.9 g).

Quelle