Reaktion #1869198

Reaktionsgleichung

quinolinone

DMF

phosphorus tribromide

sodium carbonate

→

solid

10-Bromo-2,3-dihydro-[1,4]dioxino[2,3-f]quinoline

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturcooling for 30 minutes
2. 2
   workup.STIRRINGstirred for a further 2 hours
3. 3
   TemperaturIt was cooled in ice
4. 4
   Sonstigethe solid was collected
5. 5
   Waschenwashed well with water
6. 6
   Sonstigedried in vacuo

Vorschrift

The quinolinone (4d) in dry DMF (8 mL) was cooled in ice and phosphorus tribromide (0.7 mL) added drop-wise, and the mixture was stirred, with ice-cooling for 30 minutes then allowed to warm to room temperature and stirred for a further 2 hours. It was cooled in ice and sodium carbonate solution was added and the solid was collected, washed well with water, and dried in vacuo, to afford a pale yellow solid (1.65 g).

Quelle