Reaktion #1869194

Reaktionsgleichung

2-chloro-8-benzyloxyquinoline

NaOMe

→

oil

Ausbeute 92.0%

8-Benzyloxy-2-methoxyquinoline

Ausbeute 92.0%

Lösungsmittel

toluene

MeOH

Reaktionsbedingungen

Aufarbeitung

1. 1
   TemperaturThe reaction solution was heated
2. 2
   TemperaturAfter cooling to room temperature
3. 3
   workup.ADDITIONthe reaction solution was poured onto ice
4. 4
   Extraktionextracted with toluene
5. 5
   TrocknenThe combined organic extracts were dried (MgSO4)
6. 6
   Einengenconcentrated in vacuo

Vorschrift

The crude 2-chloro-8-benzyloxyquinoline from above was dissolved in toluene (10 mL) and added to a stirred 25 wt % solution of NaOMe in MeOH (50 mL). The reaction solution was heated with stirring overnight at 70° C. After cooling to room temperature, the reaction solution was poured onto ice and extracted with toluene. The combined organic extracts were dried (MgSO4) and concentrated in vacuo to give a colorless oil (6.14 g, 92%). The product was used without further purification.

Quelle