Reaktion #1869192

Reaktionsgleichung

hydroxypyridine

2-Bromo-5-hydroxy-6-nitropyridine

potassium carbonate

Et2O

→

material

Ausbeute 89.0%

Ethyl (6-bromo-2-nitro-pyridin-3-yloxy)acetate

Ausbeute 89.0%

Lösungsmittel

acetone

Reaktionsbedingungen

Aufarbeitung

1. 1
   TemperaturThe reaction was heated
2. 2
   Temperaturat reflux for 10 hours
3. 3
   SonstigeThe precipitate was removed by suction filtration
4. 4
   Einengenthe filtrate was concentrated in vacuo

Vorschrift

The hydroxypyridine (f) (30 g, 0.14 mol) was suspended in acetone (200 ml), and potassium carbonate (39 g, 0.28 mol) was added, followed by ethyl bromoacetate (15.7 ml, 0.14 mmol). The reaction was heated at reflux for 10 hours, then was cooled to room temperature and diluted with Et2O. The precipitate was removed by suction filtration, and the filtrate was concentrated in vacuo to afford material (38 g, 89%), which was used without further purification.

Quelle