Reaktion #1869189

Reaktionsgleichung

( c )

4-Bromo-quinoline-6-carbonitrile

vinyltributyltin

→

product

Ausbeute 64.5%

4-Vinyl-quinoline-6-carbonitrile

Ausbeute 64.5%

Lösungsmittel

toluene

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturthe mixture was refluxed under argon for 2 hours
2. 2
   SonstigeEvaporation and flash silica chromatography
3. 3
   Wascheneluting with chloroform

Vorschrift

To a solution of (c) (1 g, 4.3 mmol) and vinyltributyltin (1.5 mL, 5.17 mmol) in degassed toluene (20 ml) was added tetrakis(triphenylphosphine) palladium (0) (245 mg, 5 mol %) and the mixture was refluxed under argon for 2 hours. Evaporation and flash silica chromatography eluting with chloroform afforded the product as a pale yellow solid (500 mg, 64%).

Quelle