Reaktion #1869188

Reaktionsgleichung

( b )

4-Oxo-1,4-dihydro-quinoline-6-carbonitrile

phosphorous tribromide

→

product

Ausbeute 87.0%

4-Bromo-quinoline-6-carbonitrile

Ausbeute 87.0%

Lösungsmittel

—

ice water

DMF

water

Reaktionsbedingungen

Aufarbeitung

1. 1
   FiltrationThe product was filtered off
2. 2
   Waschenwashed with water and air
3. 3
   Sonstigedried

Vorschrift

To a solution of (b) (12 g, 70.5 mmol) in DMF (75 ml) was added dropwise phosphorous tribromide (8 ml, 84.6 mmol) over five minutes (slightly exothermic). The reaction was allowed to cool to room temperature and was then diluted with ice water (100 ml) and stirred 1 hour then diluted with additional water (300 ml). The product was filtered off, washed with water and air dried to provide 14.3 g of product (87%).

Quelle