Reaktion #1868678

Reaktionsgleichung

hydrochloric acid

diphenylacetonitrile

DBU

ethyl acrylate

→

title compound

Ethyl 4-cyano-4,4-diphenylbutyrate

Lösungsmittel

ethanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturthe mixture was heated
2. 2
   TemperaturAfter cooling
3. 3
   Extraktionthe mixture was extracted with isopropyl ether
4. 4
   WaschenThe organic layer was washed with water
5. 5
   Trocknendried over anhydrous magnesium sulfate
6. 6
   Einengenconcentrated under reduced pressure
7. 7
   SonstigeThe crude crystal crop was recrystallized from hexaneisopropyl ether

Vorschrift

To a solution of diphenylacetonitrile (28 g) in ethanol (100 ml) were added DBU (6 ml) and ethyl acrylate (30 ml), and the mixture was heated and stirred at 80° C. for 16 hours. After cooling, 2N-hydrochloric acid (200 ml) was added and the mixture was extracted with isopropyl ether. The organic layer was washed with water, dried over anhydrous magnesium sulfate, and concentrated under reduced pressure. The crude crystal crop was recrystallized from hexaneisopropyl ether to provide the title compound (34 g).

Quelle