Reaktion #1865083

ord-a378eda7b4ee46a6955c6aa3a4941ab3

Reaktionsgleichung

N#Cc1cnc(N)cc1F
intermediate 21
N#Cc1cnc(N)cc1F
6-amino-4-fluoronicotinonitrile
CN1CCC[C@H]1CO
(S)-(1-methylpyrrolidin-2-yl)methanol
→
CN1CCC[C@H]1COc1cc(N)ncc1C#N
(S)-6-amino-4-((1-methylpyrrolidin-2-yl)methoxy)nicotinonitrile

Edukte

N#Cc1cnc(N)cc1F
intermediate 21
N#Cc1cnc(N)cc1F
6-amino-4-fluoronicotinonitrile
CN1CCC[C@H]1CO
(S)-(1-methylpyrrolidin-2-yl)methanol
—
intermediate 47

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

From intermediate 21 and (S)-(1-methylpyrrolidin-2-yl)methanol, reacted in an analogous manner to the preparation of intermediate 47. (UPLC-MS 3) tR 0.30 min; ESI-MS 233.2 [M+H]+.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US09266883B2uspto-grants-2016_02