Reaktion #1864294

Reaktionsgleichung

ethyl 2-(4-acetamidophenoxy)acetate

NaOH

→

title compound

2-(4-acetamidophenoxy)acetic acid

Lösungsmittel

EtOH

Reaktionsbedingungen

Aufarbeitung

1. 1
   Einengenconcentrated
2. 2
   workup.ADDITIONThe residue was diluted with water (20 mL)
3. 3
   Waschenwashed ethyl acetate (2×20 mL)
4. 4
   Extraktionextracted with ethyl acetate (2×20 ml)
5. 5
   WaschenThe combined organic layers were washed with brine (30 mL)
6. 6
   Trocknendried over Na2SO4
7. 7
   Einengenconcentrated

Vorschrift

To a solution of ethyl 2-(4-acetamidophenoxy)acetate (237 mg, 1 mmol) in EtOH (10 ml) was added 10% NaOH aqueous solution (10 mL) at 26° C. The mixture was stirred for 30 min and then concentrated. The residue was diluted with water (20 mL) and washed ethyl acetate (2×20 mL). The aqueous layer was then acidified with 2N HCL until pH 3 and extracted with ethyl acetate (2×20 ml). The combined organic layers were washed with brine (30 mL), dried over Na2SO4 and concentrated to give the title compound which was used in next step without further purification.

Quelle