Reaktion #1863618

Reaktionsgleichung

2-[1-(2-fluorobenzyl)-1H-indazol-3-yl]-4-(pyridin-4-ylamino)pyrimidine-5-carbonitrile

sulfuric acid

→

2-[1-(2-fluorobenzyl)-1H-indazol-3-yl]-4-(pyridin-4-ylamino)pyrimidine-5-carboxamide

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.ADDITIONIce was added to the suspension
2. 2
   FiltrationThe suspension was filtered off
3. 3
   Waschenwashed with water
4. 4
   Sonstigethe filter cake was dried under vacuo at 50° C.
5. 5
   Sonstigeto yield 23.0 mg (0.05 mmol, 106%) of the analytically pure target compound

Vorschrift

20.7 mg of 2-[1-(2-fluorobenzyl)-1H-indazol-3-yl]-4-(pyridin-4-ylamino)pyrimidine-5-carbonitrile (31-1, 0.049 mmol, 1 eq.) were added to ice bath cooled conc. sulfuric acid (1.84 mmol, 37.5 eq.) and stirred for five minutes at 5° C. and further 24 hours at room temperature. Ice was added to the suspension. The suspension was filtered off, washed with water and the filter cake was dried under vacuo at 50° C. to yield 23.0 mg (0.05 mmol, 106%) of the analytically pure target compound.

Quelle