Reaktion #1859583

Reaktionsgleichung

compound 12

4-(3,5-Di-tert-butylphenyl)-2-((1-methylcyclohexyl)methylene)-2,3-dihydro-1H-inden-1-one

→

crude compound 13

Ausbeute 80.0%

4-(3,5-Di-tert-butylphenyl)-2-((1-methylcyclohexyl)methyl)-2,3-dihydro-1H-inden-1-one

Ausbeute 80.0%

Lösungsmittel

ethanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigeat room temperature
2. 2
   Sonstigefor 4 hours
3. 3
   FiltrationThe mixture was filtered through Celite
4. 4
   Waschenthe filter cake was washed with ethanol (500 mL)
5. 5
   EinengenThe filtrate was concentrated under reduced pressure

Vorschrift

A mixture of Raney nickel (slurry in water, 12.5 g), compound 12 (12.5 g, 29.16 mmol, 1 equiv) and ethanol (1000 mL) was hydrogenated @ 50 psi at room temperature for 4 hours. The mixture was filtered through Celite and the filter cake was washed with ethanol (500 mL). The filtrate was concentrated under reduced pressure to give crude compound 13 (10.0 g, 80% yield) as a pale-yellow oil. This material was used subsequently.

Quelle