Reaktion #1859537

Reaktionsgleichung

Compound 202

(1S,2R)-4′-(4-chlorophenyl)-2-(methoxymethyl)-2′,3′,9′-trimethylspiro[cyclopropane-1,6′-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine]

racemic (1S,2R)-5′-(4-chlorophenyl)-2,6′,7′-trimethylspiro[cyclopropane-1,3′-thieno[2,3-e][1,4]diazepin]-2′(1′H)-one

→

Racemic 4′-(4-chlorophenyl)-2,2′,3′,9′-tetramethylspiro[cyclopropane-1,6′-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine]

Reaktionsbedingungen

Vorschrift

A procedure analogous to that set forth for Compound 202 was followed, with the exception that racemic (1S,2R)-5′-(4-chlorophenyl)-2,6′,7′-trimethylspiro[cyclopropane-1,3′-thieno[2,3-e][1,4]diazepin]-2′(1′H)-one was used as starting material. LRMS (M+H)+: 383 m/z. 1H NMR (400 MHz, DMSO-d6) δ 7.50 (s, 4H), 2.59 (s, 3H), 2.39 (s, 3H), 1.96-2.02 (m, 1H), 1.58 (s, 3H), 1.39 (d, J=6.18 Hz, 1H), 1.04 (d, J=5.95 Hz, 1H), 0.79 (d, J=5.49 Hz, 3H).

Quelle