Reaktion #1859534

Reaktionsgleichung

Compound 202

(1S,2R)-4′-(4-chlorophenyl)-2-(methoxymethyl)-2′,3′,9′-trimethylspiro[cyclopropane-1,6′-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine]

5′-(4-chlorophenyl)-6′,7′-dimethylspiro[cyclopropane-1,3′-thieno[2,3-e][1,4]diazepin]-2′(1′H)-one

→

4′-(4-Chlorophenyl)-2′,3′,9′-trimethylspiro[cyclopropane-1,6′-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine]

Reaktionsbedingungen

Vorschrift

A procedure analogous to that set forth for Compound 202 was followed, with the exception that 5′-(4-chlorophenyl)-6′,7′-dimethylspiro[cyclopropane-1,3′-thieno[2,3-e][1,4]diazepin]-2′(1′H)-one was used as starting material. LRMS (M+H)+: 369 m/z. 1H NMR (400 MHz, DMSO-d6) δ 7.39-7.57 (m, 4H), 2.60 (s, 3H), 2.39 (s, 3H), 1.67-1.83 (m, 1H), 1.57 (s, 3H), 1.33-1.45 (m, 1H), 0.83 (t, J=8.47 Hz, 2H).

Quelle