Reaktion #1859532

Reaktionsgleichung

Compound 202

(1S,2R)-4′-(4-chlorophenyl)-2-(methoxymethyl)-2′,3′,9′-trimethylspiro[cyclopropane-1,6′-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine]

4′-(4-chlorophenyl)-3′-methylspiro[cyclopropane-1,6′-isothiazolo[5,4-e][1,4]diazepin]-7′(8′H)-one

→

4′-(4-Chlorophenyl)-3′,9′-dimethylspiro[cyclopropane-1,6′-isothiazolo[4,5-f][1,2,4]triazolo[4,3-a][1,4]diazepine]

Reaktionsbedingungen

Vorschrift

A procedure analogous to that set forth for Compound 202 was followed, with the exception that 4′-(4-chlorophenyl)-3′-methylspiro[cyclopropane-1,6′-isothiazolo[5,4-e][1,4]diazepin]-7′(8′H)-one was used as starting material. LRMS (M+H)+: 356 m/z. 1H NMR (400 MHz, DMSO-d6) δ 7.25-7.65 (m, 4H), 2.62 (br. s., 3H), 1.91 (s, 3H), 1.85-1.89 (m, 2H), 1.78-1.82 (m, 2H).

Quelle