Reaktion #1858600

Reaktionsgleichung

2-(5-bromo-1-methylisochroman-1-yl)-4,5-dihydro-1H-imidazole

2-(5-Bromo-1-methylisochroman-1-yl)-4,5-dihydro-1H-imidazole

sodium carbonate

cyclopropylboronic acid

water

→

2-(5-Cyclopropylisochroman-1-yl)-4,5-dihydro-1H-imidazole

Lösungsmittel

acetonitrile

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe title compound was purified with separation methods A and G

Vorschrift

The mixture of 2-(5-bromo-1-methylisochroman-1-yl)-4,5-dihydro-1H-imidazole (Example 11, 0.15 g), sodium carbonate (0.27 g), bis(triphenylphosphine)palladium(II) chloride (0.02 g), cyclopropylboronic acid (0.09 g), water (1 ml), and acetonitrile (2 ml) was heated in a microwave oven at 120° C. for 15 min. The title compound was purified with separation methods A and G. (Yield 8 mg).

Quelle