Reaktion #1857576

Reaktionsgleichung

tert-butyl 4-(4-formyl-1,3-thiazol-2-yl)piperidine-1-carboxylate

hydrogen chloride

→

4-(4-Formyl-1,3-thiazol-2-yl)piperidinium chloride

Lösungsmittel

1,4-dioxane

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturgradually warmed to room temperature
2. 2
   workup.STIRRINGAfter stirring overnight
3. 3
   Sonstigethe solvent and excess hydrogen chloride were removed

Vorschrift

To tert-butyl 4-(4-formyl-1,3-thiazol-2-yl)piperidine-1-carboxylate (10 g) was added dropwise, at 0° C., a 4 molar solution of hydrogen chloride in 1,4-dioxane (100 ml). The reaction mixture was stirred at 0° C. and then gradually warmed to room temperature. After stirring overnight, the solvent and excess hydrogen chloride were removed. This gave 4-(4-formyl-1,3-thiazol-2-yl)piperidinium chloride (9 g).

Quelle