Reaktion #1857547

Reaktionsgleichung

dichloro methane

sodium hydride

2-[2-chloro-4-(4-chlorophenoxy)phenyl]-1-(1,2,4-triazol-1-yl)but-3-en-2-ol

methyl iodide

→

desired compound

1-[2-[2-chloro-4-(4-chlorophenoxy)phenyl]-2-methoxy-but-3-enyl]-1,2,4-triazole

Lösungsmittel

Brine

THF

Reaktionsbedingungen

Aufarbeitung

1. 1
   TemperaturThe mixture was then heated for 10 h
2. 2
   Temperaturto reflux
3. 3
   Sonstigethe organic phase was dried
4. 4
   Sonstigeevaporated
5. 5
   Sonstigeto obtain the crude product
6. 6
   SonstigeThis was purified by column chromatography

Vorschrift

2-[2-chloro-4-(4-chlorophenoxy)phenyl]-1-(1,2,4-triazol-1-yl)but-3-en-2-ol (0.4 g) was dissolved in THF (10 mL) and sodium hydride (0.03 g) was added. The mixture was stirred for 30 min at room temperature and methyl iodide (0.08 mL) was added. The mixture was then heated for 10 h to reflux. Brine and dichloro methane were added, the organic phase was dried and evaporated to obtain the crude product. This was purified by column chromatography to obtain 0.04 g of the desired compound.

Quelle